Could seaweed end our plastic pollution problem?

Some people seem to have infinite energy to conquer any challenges in life. Julia and Michael are two of a few that I have met that extrude this characteristic.

I met Julia and Michael through the Startmate Office Hours last year after I…


MIT Tech Review just released 10 Breakthrough Technologies in 2021, and our team at Main Sequence have seen and invested in several areas mentioned in the list:

  • Messenger RNA vaccines

While the world is watching the development of mRNA vaccines closely, we have seen opportunities in mRNA diagnostics. mRNA tests…


If I have to name one thing that I learned working in a fast-paced team, I would say that trust is vital for a highly effective team. This is particularly true for startups where many things are happening at the same time. …


Investors valuate startups based on assumptions.

Multiple-based valuation assumes that companies in the same industry with a similar growth rate will create similar value.

Comparable company analysis assumes that two different companies working on the same problem to a certain level have a similar growth trajectory.

DCF assumes that the…


I visited Cockatoo Island for Biennale a few weeks ago and there was an exhibition on the plastic from the ocean and the impact on the wild animals and our ecosystem. This exhibition prompted me to study more about the problem.

I spent a few mornings researching, and here is…


Time management tips from a psychiatrist

If you are reading news or checking emails the first thing in the morning, you are doing it wrong.

One of the most practical books that I have read this year is 脳のパフォーマンスを最大まで引き出す 神・時間術 by a Japanese psychiatrist 樺沢 紫苑. This book talks about how we can manage time from…


If you are a founder pitching to VCs for the first time, here is a 101 guide to the jargons that VCs often use. Don’t worry. We live in the same world.

Let’s get started.

LP
* LP means limited partner, who provides funding to VC firms without making investment…


Dr. Nancy A Schellhorn — CEO and Co-founder of RapidAIM

What do you find particularly challenging in your current role?

I feel like I’m writing the script of a play and performing in it all at the same time. I’m also directing the cast, who are all brilliant actors! However…


I admire humorous people. David Nihill’s book on comedy habits to become a better and funnier public speaker answered questions I have long had about those people.

I was relieved to know that even when some funny speakers seem calm, they might be sweating on the stage. What’s even better…


The Coronavirus outbreak in China since December 2019 has influenced the daily life of billions. While many people stay at home with the extended Chinese New Year holiday, tech is playing a significant role in the fight against the deadly virus.

I spent last week in China and here are…

Stella Xu

deeptech investing @mseq.vc

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